1392820-18-6

1392820-18-6 structure

Name: 27-O-(tert-Butyldimethylsilyl)withaferin A
Chemical Name: 27-O-(tert-Butyldimethylsilyl)withaferin A
CAS Number: 1392820-18-6
Molecular Formula: C₃₄H₅₂O₆Si
Molecular Weight: 584.86
Create Date: 2022-06-04 11:15:45
Modify Date: 2024-01-18 13:49:47
27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells[1].

Name	27-O-(tert-Butyldimethylsilyl)withaferin A

Description	27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a; 32 μM; 4-8 hours) inhibits caspase-3 activity in HeLa cells[1]. 27-O-(tert-Butyldimethylsilyl)withaferin A (48 hours) shows antiproliferative activity against HeLa, A-549, MCF-7, and Vero cells with IC50 values of 0.9 μM, 1.5 μM, 0.7 μM, and 0.7 μM, respectively[1].
References	[1]. Gabriel G Llanos, et al. Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells. Eur J Med Chem. 2012 Aug;54:499-511.

Molecular Formula	C₃₄H₅₂O₆Si
Molecular Weight	584.86