2170491-77-5

2170491-77-5 structure

Name: AMXI-5001
Chemical Name: AMXI-5001
CAS Number: 2170491-77-5
Molecular Formula: C₂₅H₂₀FN₅O₃
Molecular Weight: 457.46
Create Date: 2022-06-09 19:53:19
Modify Date: 2025-08-25 19:18:33
AMXI-5001 is a potent, orally active, and dual parp1/2 and microtubule polymerization inhibitor. MXI-5001 exhibits selective antitumor cytotoxicity across a wide variety of human cancer cells with much lower IC50s than existing clinical PARP1/2 inhibitors. AMXI-5001 induces complete regression of established tumors, including exceedingly large tumors[1].

Name	AMXI-5001

Description	AMXI-5001 is a potent, orally active, and dual parp1/2 and microtubule polymerization inhibitor. MXI-5001 exhibits selective antitumor cytotoxicity across a wide variety of human cancer cells with much lower IC50s than existing clinical PARP1/2 inhibitors. AMXI-5001 induces complete regression of established tumors, including exceedingly large tumors[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
References	[1]. Lemjabbar-Alaoui H, et al. AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers. Am J Cancer Res. 2020;10(8):2649-2676.

Molecular Formula	C₂₅H₂₀FN₅O₃
Molecular Weight	457.46