MI-389

Modify Date: 2024-01-10 11:11:11

MI-389 Structure
MI-389 structure
Common Name MI-389
CAS Number 2222635-92-7 Molecular Weight 654.69
Density N/A Boiling Point N/A
Molecular Formula C35H35FN6O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MI-389


MI-389 is a PROTAC translation termination factor GSPT1 degrader. MI-389 disrupts a target that is a shared dependency in different AML and ALL cell lines, and that MI-389 action is dependent on the CRL4CRBN E3 ligase[1].

 Names

Name MI-389

 MI-389 Biological Activity

Description MI-389 is a PROTAC translation termination factor GSPT1 degrader. MI-389 disrupts a target that is a shared dependency in different AML and ALL cell lines, and that MI-389 action is dependent on the CRL4CRBN E3 ligase[1].
Related Catalog
Target

Cereblon

References

[1]. Ishoey M, et al. Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders. ACS Chem Biol. 2018;13(3):553-560.

 Chemical & Physical Properties

Molecular Formula C35H35FN6O6
Molecular Weight 654.69
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