Name | D-arabino-Hexitol, 5-amino-2,6-anhydro-1,3,4,5-tetradeoxy-6-C-(2,5-difluorophenyl)-3-[2,6-dihydro-2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(4H)-yl]-1,1,1-trifluoro-, (6R)- |
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Synonyms | Cofrogliptin (HSK7653) (compound 2) |
Description | Cofrogliptin (HSK7653) (compound 2), a tetrahydropyran derivative, is a potent oral dipeptidyl aminopeptidase 4 (DPP-4) inhibitor with Long-acting antidiabetic efficacy. Cofrogliptin (compound 2) has a great potential for type 2 diabetes mellitus (T2DM) [1]. |
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Related Catalog | |
Target |
IC50: 4.18 nM (DPP-4) [2] |
In Vitro | Cofrogliptin (HSK7653) (compound 2) has the DPP-4 inhibitory activity with an IC50 value of 4.18 nM[2]. |
References |
[1]. International Nonproprietary Names for Pharmaceutical Substances (INN) |
Molecular Formula | C18H19F5N4O3S |
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Molecular Weight | 466.43 |