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2649882-80-2

2649882-80-2 structure
2649882-80-2 structure
  • Name: ARN25068
  • Chemical Name: ARN25068
  • CAS Number: 2649882-80-2
  • Molecular Formula: C19H18N6S
  • Molecular Weight: 362.45
  • Catalog: Signaling Pathways PI3K/Akt/mTOR GSK-3
  • Create Date: 2022-05-21 17:31:45
  • Modify Date: 2024-01-21 09:21:34
  • ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation[1].

Name ARN25068
Description ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation[1].
Related Catalog
In Vitro ARN25068 reduces the extent of tau phosphorylation in Tau0N4R-TM-tGFP U2OS cell line. ARN25068 exhibits IC50 values of 4.17 and 2.17 μM for GSK-3β and FYN in enzymatic radiometric assay, respectively[1].
References

[1]. Stefania Demuro, et al. ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur J Med Chem. 2022 Feb 5;229:114054.

Molecular Formula C19H18N6S
Molecular Weight 362.45
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