ARN25068

Modify Date: 2025-08-25 11:49:34

ARN25068 structure	Common Name	ARN25068
	CAS Number	2649882-80-2	Molecular Weight	362.45
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₈N₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ARN25068

ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation[1].

Name	ARN25068

Description	ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
In Vitro	ARN25068 reduces the extent of tau phosphorylation in Tau0N4R-TM-tGFP U2OS cell line. ARN25068 exhibits IC50 values of 4.17 and 2.17 μM for GSK-3β and FYN in enzymatic radiometric assay, respectively[1].
References	[1]. Stefania Demuro, et al. ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur J Med Chem. 2022 Feb 5;229:114054.

Molecular Formula	C₁₉H₁₈N₆S
Molecular Weight	362.45
InChIKey	TVUWQDLBEOZVOU-UHFFFAOYSA-N
SMILES	c1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3sccc3n2)cc1

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ARN25068
Price: Check
Purity: 99.71%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: ARN25068
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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