2484811-52-9

2484811-52-9 structure

Name: ATX inhibitor 15
Chemical Name: ATX inhibitor 15
CAS Number: 2484811-52-9
Molecular Formula: C₁₉H₁₉F₃N₂O₃
Molecular Weight: 380.36
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2022-06-15 10:21:01
Modify Date: 2024-01-12 20:39:24
ATX inhibitor 15 (compound 30), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC50 of 2.17 nM. ATX inhibitor 15 inhibits in vivo ATX and the gene expression of pro-fibrotic factors. ATX inhibitor 15 has lung protection effects in Bleomycin challenged mice lung fibrosis model[1].

Name	ATX inhibitor 15

Description	ATX inhibitor 15 (compound 30), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC50 of 2.17 nM. ATX inhibitor 15 inhibits in vivo ATX and the gene expression of pro-fibrotic factors. ATX inhibitor 15 has lung protection effects in Bleomycin challenged mice lung fibrosis model[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
Target	Autotaxin:2.17 nM (IC50)
References	[1]. Hongrui Lei, et al. Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model. Eur J Med Chem. 2022 Jan 5;227:113951.

Molecular Formula	C₁₉H₁₉F₃N₂O₃
Molecular Weight	380.36