2669785-77-5

2669785-77-5 structure

Name: JPS016
Chemical Name: JPS016
CAS Number: 2669785-77-5
Molecular Formula: C₄₈H₆₃N₇O₈S
Molecular Weight: 898.12
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2022-05-21 10:59:34
Modify Date: 2024-01-09 22:52:22
JPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS016 degrades class I histone deacetylase (HDAC). JPS016 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].

Name	JPS016

Description	JPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS016 degrades class I histone deacetylase (HDAC). JPS016 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Epigenetics >> HDAC
References	[1]. Smalley JP, et al. Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells. J Med Chem. 2022;65(7):5642-5659.

Molecular Formula	C₄₈H₆₃N₇O₈S
Molecular Weight	898.12