170488-57-0
170488-57-0 structure
- Name: Tubulin inhibitor 23
- Chemical Name: Tubulin inhibitor 23
- CAS Number: 170488-57-0
- Molecular Formula: C26H23NO6S
- Molecular Weight: 477.53
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-05-22 19:57:07
- Modify Date: 2024-01-04 11:01:15
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Tubulin inhibitor 23 is a potent Tubulin inhibitor with an IC50 of 4.8 µM. Tubulin inhibitor 23 induces cell apoptosis. Tubulin inhibitor 23 shows antiangiogenic activity in a dose-dependent manner. Tubulin inhibitor 23 has the potential for the research of leukaemia[1].
| Name | Tubulin inhibitor 23 |
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| Description | Tubulin inhibitor 23 is a potent Tubulin inhibitor with an IC50 of 4.8 µM. Tubulin inhibitor 23 induces cell apoptosis. Tubulin inhibitor 23 shows antiangiogenic activity in a dose-dependent manner. Tubulin inhibitor 23 has the potential for the research of leukaemia[1]. |
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| Related Catalog | |
| Target |
IC50: 4.8 µM (Tubulin)[1] |
| In Vitro | Tubulin inhibitor 23 (compound 29e) (0-100 µM) inhibits tubulin polymerisation (IC50=4.8 µM) and anti-angiogenesis (IC50=3.4 µM) in Zebrafish[1]. Tubulin inhibitor 23 (0-200 nM; 48 h) induces cell apoptosis in a concentration-dependent manner[1]. Tubulin inhibitor 23 (0-20 µM; 0-29 min) binds to the colchicine site of tubulin and inhibit the microtubule polymerisation[1]. Tubulin inhibitor 23 (0.1, 1, 10 µM; 1 h) shows anti-angiogenesis activity with low toxicity (IC50=58.6 µM) in Human umbilical vein endothelial cells (HUVECs)[1]. Cell Proliferation Assay[1] Cell Line: MV4-11, HL60, K562, THP-1,CCRF-CEM, Jurkat, HuT 78 cells Concentration: Incubation Time: 72 h Result: Showed potent growth inhibitory activity with IC50s of 0.25, 0.18, 0.09, 0.37, 0.84, 1.22, 0.26 µM for MV4-11, HL60, K562, THP-1,CCRF-CEM, Jurkat, HuT 78 cells, respectively. Apoptosis Analysis[1] Cell Line: K562 cells Concentration: 0, 50, 100, 200 nM Incubation Time: 48 h Result: The percentage of apoptotic cell significantly increased from 5.95% to 45.81%. Western Blot Analysis[1] Cell Line: K562 cells Concentration: 0, 50, 100, 200 nM Incubation Time: 48 h Result: Increased the expression of cleaved caspase-3 and PARP. |
| In Vivo | Tubulin inhibitor 23 (2, 6 µM; add into embryo water) shows antiangiogenic activity in a dose-dependent manner[1]. Tubulin inhibitor 23 (2, 6 µM; add into embryo water) suppresses the proliferation and metastasis of K562 cells in zebrafish xenografts in a dose-dependent manner[1]. Animal Model: 3hpf zebrafish embryos[1] Dosage: 2.0, 6.0 µM Administration: Add into embryo water Result: Decreased the number and length of ISVs (intersegmental vessels) in a dose-dependent inhibition pattern. Animal Model: Transgenic zebrafish (fil1:EGFP) (K562 cell xenograft)[1] Dosage: 2, 6 µM Administration: Add into embryo water Result: Reduced intensities and decreased tumour area. |
| References |
| Molecular Formula | C26H23NO6S |
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| Molecular Weight | 477.53 |