2761146-51-2

2761146-51-2 structure

Name: VPC-13789
Chemical Name: VPC-13789
CAS Number: 2761146-51-2
Molecular Formula: C₂₁H₁₆F₃N₃O
Molecular Weight: 383.37
Catalog: Research Areas Cancer
Create Date: 2022-05-20 20:08:59
Modify Date: 2024-04-01 18:07:51
VPC-13789 is a potent, selective, and orally bioavailable antiandrogen. VPC-13789 can be used for the research of castration-resistant prostate cancer (CRPC) therapeutics. VPC-13789 inhibits androgen receptor (AR) transcriptional activity in LNCaP cells (IC50=0.19 μM)[1].

Name	VPC-13789

Description	VPC-13789 is a potent, selective, and orally bioavailable antiandrogen. VPC-13789 can be used for the research of castration-resistant prostate cancer (CRPC) therapeutics. VPC-13789 inhibits androgen receptor (AR) transcriptional activity in LNCaP cells (IC50=0.19 μM)[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Endocrinology Signaling Pathways >> Others >> Androgen Receptor
References	[1]. Eric Leblanc , et al. Development of 2-(5,6,7-Trifluoro-1 H-Indol-3-yl)-quinoline-5-carboxamide as a Potent, Selective, and Orally Available Inhibitor of Human Androgen Receptor Targeting Its Binding Function-3 for the Treatment of Castration-Resistant Prostate Cancer. J Med Chem. 2021 Oct 28;64(20):14968-14982.

Molecular Formula	C₂₁H₁₆F₃N₃O
Molecular Weight	383.37