1011366-31-6
1011366-31-6 structure
- Name: MCI-INI-3
- Chemical Name: MCI-INI-3
- CAS Number: 1011366-31-6
- Molecular Formula: C21H15N3O4
- Molecular Weight: 373.368
- Create Date: 2022-07-01 08:55:55
- Modify Date: 2024-01-15 00:12:44
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MCI-INI-3 is a potent, selective, competitive inhibitor of ALDH1A3 (Ki=0.55 uM), shows poor inhibitory effect on the structurally related isoform ALDH1A1 (>140-fold selectivity).MCI-INI-3 also displays on inhibition against six isoforms of ALDH (ALDH16A1, ALDH7A1, ALDH9A1, ALDH2, ALDH1B1, ALDH18A1).MCI-INI-3 demonstrates selective binding to ALDH1A3 in glioma stem cell lysates, inhibits ALDH activity and affects RA synthesis in cells.
| Name | MCI-INI-3 |
|---|
| Description | MCI-INI-3 is a potent, selective, competitive inhibitor of ALDH1A3 (Ki=0.55 uM), shows poor inhibitory effect on the structurally related isoform ALDH1A1 (>140-fold selectivity).MCI-INI-3 also displays on inhibition against six isoforms of ALDH (ALDH16A1, ALDH7A1, ALDH9A1, ALDH2, ALDH1B1, ALDH18A1).MCI-INI-3 demonstrates selective binding to ALDH1A3 in glioma stem cell lysates, inhibits ALDH activity and affects RA synthesis in cells. |
|---|---|
| References | 1. Jianfeng Li, et al. Commun Biol. 2021 Dec 21;4(1):1420. |
| Molecular Formula | C21H15N3O4 |
|---|---|
| Molecular Weight | 373.368 |