MCI-INI-3 structure
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Common Name | MCI-INI-3 | ||
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CAS Number | 1011366-31-6 | Molecular Weight | 373.368 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C21H15N3O4 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of MCI-INI-3MCI-INI-3 is a potent, selective, competitive inhibitor of ALDH1A3 (Ki=0.55 uM), shows poor inhibitory effect on the structurally related isoform ALDH1A1 (>140-fold selectivity).MCI-INI-3 also displays on inhibition against six isoforms of ALDH (ALDH16A1, ALDH7A1, ALDH9A1, ALDH2, ALDH1B1, ALDH18A1).MCI-INI-3 demonstrates selective binding to ALDH1A3 in glioma stem cell lysates, inhibits ALDH activity and affects RA synthesis in cells. |
Name | MCI-INI-3 |
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Description | MCI-INI-3 is a potent, selective, competitive inhibitor of ALDH1A3 (Ki=0.55 uM), shows poor inhibitory effect on the structurally related isoform ALDH1A1 (>140-fold selectivity).MCI-INI-3 also displays on inhibition against six isoforms of ALDH (ALDH16A1, ALDH7A1, ALDH9A1, ALDH2, ALDH1B1, ALDH18A1).MCI-INI-3 demonstrates selective binding to ALDH1A3 in glioma stem cell lysates, inhibits ALDH activity and affects RA synthesis in cells. |
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References | 1. Jianfeng Li, et al. Commun Biol. 2021 Dec 21;4(1):1420. |
Molecular Formula | C21H15N3O4 |
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Molecular Weight | 373.368 |