1609341-78-7
1609341-78-7 structure
- Name: BAY-747
- Chemical Name: BAY-747
- CAS Number: 1609341-78-7
- Molecular Formula: C22H26F2N4O2
- Molecular Weight: 416.473
- Create Date: 2022-07-02 17:44:08
- Modify Date: 2024-04-06 11:40:55
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BAY-747 (BAY747) is a novel potent, selective, brain-penetrant soluble guanylate cyclase (sGC) stimulator.Oral administration of BAY-747 to male Wistar rats enhanced memory acquisition in the object location task (OLT), reversed L-NAME induced memory impairments in the OLT.BAY-747 enhanced hippocampal GluA1-containing AMPA receptor (AMPAR) trafficking in a chemical LTP model for memory acquisition using acute mouse hippocampal slices in ex vivo.
| Name | BAY-747 |
|---|
| Description | BAY-747 (BAY747) is a novel potent, selective, brain-penetrant soluble guanylate cyclase (sGC) stimulator.Oral administration of BAY-747 to male Wistar rats enhanced memory acquisition in the object location task (OLT), reversed L-NAME induced memory impairments in the OLT.BAY-747 enhanced hippocampal GluA1-containing AMPA receptor (AMPAR) trafficking in a chemical LTP model for memory acquisition using acute mouse hippocampal slices in ex vivo. |
|---|---|
| References | 1. Nelissen E, et al. Sci Rep. 2022 Mar 4;12(1):3589. |
| Molecular Formula | C22H26F2N4O2 |
|---|---|
| Molecular Weight | 416.473 |