1613509-49-1
1613509-49-1 structure
- Name: SRI-41315
- Chemical Name: SRI-41315
- CAS Number: 1613509-49-1
- Molecular Formula: C22H19N3O2
- Molecular Weight: 357.413
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel CFTR
- Create Date: 2022-07-01 11:20:19
- Modify Date: 2024-01-19 10:18:26
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SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion, restores CFTR expression and function, suppresses CFTR nonsense mutations.SRI-41315 induces translational readthrough by depleting eRF1 protein level and prolonging the translational pause that occurs at premature termination codons (PTCs).SRI-41315 reduced eRF1 levels in a manner dependent upon a ubiquitin-mediated proteasome degradation pathway.SRI-41315 in combination with G418 restores CFTR function in primary bronchial epithelial cells derived from a CF patient with CFTR nonsense alleles.
| Name | SRI-41315 |
|---|
| Description | SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion, restores CFTR expression and function, suppresses CFTR nonsense mutations.SRI-41315 induces translational readthrough by depleting eRF1 protein level and prolonging the translational pause that occurs at premature termination codons (PTCs).SRI-41315 reduced eRF1 levels in a manner dependent upon a ubiquitin-mediated proteasome degradation pathway.SRI-41315 in combination with G418 restores CFTR function in primary bronchial epithelial cells derived from a CF patient with CFTR nonsense alleles. |
|---|---|
| References | 1. Sharma J, et al. Nat Commun. 2021 Jul 16;12(1):4358. |
| Molecular Formula | C22H19N3O2 |
|---|---|
| Molecular Weight | 357.413 |