SRI-41315
Modify Date: 2024-01-19 10:18:26
SRI-41315 structure
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Common Name | SRI-41315 | ||
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| CAS Number | 1613509-49-1 | Molecular Weight | 357.413 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H19N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SRI-41315SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion, restores CFTR expression and function, suppresses CFTR nonsense mutations.SRI-41315 induces translational readthrough by depleting eRF1 protein level and prolonging the translational pause that occurs at premature termination codons (PTCs).SRI-41315 reduced eRF1 levels in a manner dependent upon a ubiquitin-mediated proteasome degradation pathway.SRI-41315 in combination with G418 restores CFTR function in primary bronchial epithelial cells derived from a CF patient with CFTR nonsense alleles. |
| Name | SRI-41315 |
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| Description | SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion, restores CFTR expression and function, suppresses CFTR nonsense mutations.SRI-41315 induces translational readthrough by depleting eRF1 protein level and prolonging the translational pause that occurs at premature termination codons (PTCs).SRI-41315 reduced eRF1 levels in a manner dependent upon a ubiquitin-mediated proteasome degradation pathway.SRI-41315 in combination with G418 restores CFTR function in primary bronchial epithelial cells derived from a CF patient with CFTR nonsense alleles. |
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| References | 1. Sharma J, et al. Nat Commun. 2021 Jul 16;12(1):4358. |
| Molecular Formula | C22H19N3O2 |
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| Molecular Weight | 357.413 |