2019223-60-8
2019223-60-8 structure
- Name: CPL302-253
- Chemical Name: CPL302-253
- CAS Number: 2019223-60-8
- Molecular Formula: C26H34N8O
- Molecular Weight: 474.613
- Create Date: 2022-07-11 10:34:03
- Modify Date: 2024-01-13 10:06:28
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CPL302-253 is a potent, selective inhibitor of PI3Kδ with IC50 of 12.2 nM and Kd of 0.83 nM, >350-fold selectivity over PI3K isoforms α, β, and γ (IC50>4,500 nM);CPL302-253 displays no off-target interaction in KinomeScan assays.CLP302-253 blocks activation of primary lymphoid cells in vitro, blocks IL-33 cytokine production in epithelial and T cell co-cultures.CLP302-253 bocks eosinophil infiltration to the lungs and IL-33 expression in HDM induced asthma mouse model.
| Name | CPL302-253 |
|---|
| Description | CPL302-253 is a potent, selective inhibitor of PI3Kδ with IC50 of 12.2 nM and Kd of 0.83 nM, >350-fold selectivity over PI3K isoforms α, β, and γ (IC50>4,500 nM);CPL302-253 displays no off-target interaction in KinomeScan assays.CLP302-253 blocks activation of primary lymphoid cells in vitro, blocks IL-33 cytokine production in epithelial and T cell co-cultures.CLP302-253 bocks eosinophil infiltration to the lungs and IL-33 expression in HDM induced asthma mouse model. |
|---|---|
| References | 1. Paweł Gunerka, et al. PLoS One. 2020 Jul 23;15(7):e0236159. |
| Molecular Formula | C26H34N8O |
|---|---|
| Molecular Weight | 474.613 |