1241280-25-0
1241280-25-0 structure
- Name: GPR183 antagonist SAE-14
- Chemical Name: GPR183 antagonist SAE-14
- CAS Number: 1241280-25-0
- Molecular Formula: C19H19F3N2O2
- Molecular Weight: 364.368
- Catalog: Signaling Pathways GPCR/G Protein EBI2/GPR183
- Create Date: 2022-07-11 21:22:30
- Modify Date: 2024-01-05 11:40:07
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GPR183 antagonist SAE-14 is a potent, selective GPR183 antagonist with IC50 of 28.5 nM, inhibits GPR183-dependent 7α,25-dihydroxycholesterol-induced calcium signaling in HL-60 cells.GPR183 antagonist SAE-14 inhibits calcium mobilization induced by 7α,25-OHC (EC80 209 nM).GPR183 antagonist SAE-14 reversed CCI-induced mechanical allodynia in a time-dependent manner when administered in vivo to mice.7α,25-dihydroxycholesterol induced allodynia in mice, SAE-14 blocked the effects of 7α,25-OHC in a dose-dependent manner.
| Name | GPR183 antagonist SAE-14 |
|---|
| Description | GPR183 antagonist SAE-14 is a potent, selective GPR183 antagonist with IC50 of 28.5 nM, inhibits GPR183-dependent 7α,25-dihydroxycholesterol-induced calcium signaling in HL-60 cells.GPR183 antagonist SAE-14 inhibits calcium mobilization induced by 7α,25-OHC (EC80 209 nM).GPR183 antagonist SAE-14 reversed CCI-induced mechanical allodynia in a time-dependent manner when administered in vivo to mice.7α,25-dihydroxycholesterol induced allodynia in mice, SAE-14 blocked the effects of 7α,25-OHC in a dose-dependent manner. |
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| References | 1. Kathryn Braden, et al. J Pharmacol Exp Ther. 2020 Nov;375(2):367-375. |
| Molecular Formula | C19H19F3N2O2 |
|---|---|
| Molecular Weight | 364.368 |