GPR183 antagonist SAE-14
Modify Date: 2024-01-05 11:40:07
GPR183 antagonist SAE-14 structure
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Common Name | GPR183 antagonist SAE-14 | ||
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| CAS Number | 1241280-25-0 | Molecular Weight | 364.368 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H19F3N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GPR183 antagonist SAE-14GPR183 antagonist SAE-14 is a potent, selective GPR183 antagonist with IC50 of 28.5 nM, inhibits GPR183-dependent 7α,25-dihydroxycholesterol-induced calcium signaling in HL-60 cells.GPR183 antagonist SAE-14 inhibits calcium mobilization induced by 7α,25-OHC (EC80 209 nM).GPR183 antagonist SAE-14 reversed CCI-induced mechanical allodynia in a time-dependent manner when administered in vivo to mice.7α,25-dihydroxycholesterol induced allodynia in mice, SAE-14 blocked the effects of 7α,25-OHC in a dose-dependent manner. |
| Name | GPR183 antagonist SAE-14 |
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| Description | GPR183 antagonist SAE-14 is a potent, selective GPR183 antagonist with IC50 of 28.5 nM, inhibits GPR183-dependent 7α,25-dihydroxycholesterol-induced calcium signaling in HL-60 cells.GPR183 antagonist SAE-14 inhibits calcium mobilization induced by 7α,25-OHC (EC80 209 nM).GPR183 antagonist SAE-14 reversed CCI-induced mechanical allodynia in a time-dependent manner when administered in vivo to mice.7α,25-dihydroxycholesterol induced allodynia in mice, SAE-14 blocked the effects of 7α,25-OHC in a dose-dependent manner. |
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| References | 1. Kathryn Braden, et al. J Pharmacol Exp Ther. 2020 Nov;375(2):367-375. |
| Molecular Formula | C19H19F3N2O2 |
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| Molecular Weight | 364.368 |