1363154-45-3
1363154-45-3 structure
- Name: GNI-50
- Chemical Name: GNI-50
- CAS Number: 1363154-45-3
- Molecular Formula: C19H22N4O4S
- Molecular Weight: 402.469
- Create Date: 2022-07-01 10:52:29
- Modify Date: 2024-04-03 12:59:08
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GNI-50 is a potent, selective Nampt inhibitor with enzyme IC50 of 7 nM, A2780 cellular IC50 of 32 nM.GNI-50 showed excellent in vivo antitumor efficacy when dosed orally in an A2780 ovarian tumor xenograft model (TGI of 97% was observed on day 17).
| Name | GNI-50 |
|---|
| Description | GNI-50 is a potent, selective Nampt inhibitor with enzyme IC50 of 7 nM, A2780 cellular IC50 of 32 nM.GNI-50 showed excellent in vivo antitumor efficacy when dosed orally in an A2780 ovarian tumor xenograft model (TGI of 97% was observed on day 17). |
|---|---|
| References | 1. Zheng X, et al. J Med Chem. 2013 Jun 27;56(12):4921-37. |
| Molecular Formula | C19H22N4O4S |
|---|---|
| Molecular Weight | 402.469 |