2747162-85-0
2747162-85-0 structure
- Name: MCUF-651
- Chemical Name: MCUF-651
- CAS Number: 2747162-85-0
- Molecular Formula: C17H22F2N4Os
- Molecular Weight: 368.447
- Create Date: 2022-07-06 19:06:05
- Modify Date: 2024-02-01 18:21:08
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MCUF-651 (MCUF651) is a small molecule guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM), potentiate ANP-mediated cGMP with EC50 of 0.45 uM (Emax=82%) in HEK293 GC-A cells.MCUF-651 enhanced ANP-mediated cGMP generation in human cardiac, renal, and fat cells and inhibited cardiomyocyte hypertrophy in vitro.MCUF-651 binds to GC-A (Kd=397 nM) and selectively enhances the binding of ANP to GC-A ( MCUF-651+ANP, Kd=0.06 nM).MCUF-651 is orally bioavailable in mice and enhances the ability of endogenous ANP and BNP to generate GC-A-mediated cGMP ex vivo.
| Name | MCUF-651 |
|---|
| Description | MCUF-651 (MCUF651) is a small molecule guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM), potentiate ANP-mediated cGMP with EC50 of 0.45 uM (Emax=82%) in HEK293 GC-A cells.MCUF-651 enhanced ANP-mediated cGMP generation in human cardiac, renal, and fat cells and inhibited cardiomyocyte hypertrophy in vitro.MCUF-651 binds to GC-A (Kd=397 nM) and selectively enhances the binding of ANP to GC-A ( MCUF-651+ANP, Kd=0.06 nM).MCUF-651 is orally bioavailable in mice and enhances the ability of endogenous ANP and BNP to generate GC-A-mediated cGMP ex vivo. |
|---|---|
| References | 1. S Jeson Sangaralingham, et al. Proc Natl Acad Sci U S A. 2021 Dec 28;118(52):e2109386118. |
| Molecular Formula | C17H22F2N4Os |
|---|---|
| Molecular Weight | 368.447 |