454473-31-5
454473-31-5 structure
- Name: KYT-36
- Chemical Name: KYT-36
- CAS Number: 454473-31-5
- Molecular Formula: C34H42N6O6
- Molecular Weight: 630.746
- Create Date: 2022-07-01 18:43:00
- Modify Date: 2024-01-13 11:25:06
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KYT-36 is a potent, selective, and bioavailable inhibitor of P. gingivalis virulence factor gingipain K (Kgp, lysine-gingipain), potently and selectively inhibits Kgp with Ki of 0.27 nM, respectively.KYT-36 consists of benzyloxycarbonyl (BOC), L-glutaminyl (GLN), methylphenylamino (MPA), L-lysinyl (LYS), and benzylcarbamoyl (BCA) moieties.KYT-36 strongly inhibited degradation of host proteins in culture supernatants and abolished thriving of P. gingivalis in cell cultures and in periodontal pockets in vivo.KYT-36 prevented Kgp-triggered vascular permeability in guinea pigs, i.e. demonstrating its efficacy against bacterial virulence in vivo, with no toxicity effects.
| Name | KYT-36 |
|---|
| Description | KYT-36 is a potent, selective, and bioavailable inhibitor of P. gingivalis virulence factor gingipain K (Kgp, lysine-gingipain), potently and selectively inhibits Kgp with Ki of 0.27 nM, respectively.KYT-36 consists of benzyloxycarbonyl (BOC), L-glutaminyl (GLN), methylphenylamino (MPA), L-lysinyl (LYS), and benzylcarbamoyl (BCA) moieties.KYT-36 strongly inhibited degradation of host proteins in culture supernatants and abolished thriving of P. gingivalis in cell cultures and in periodontal pockets in vivo.KYT-36 prevented Kgp-triggered vascular permeability in guinea pigs, i.e. demonstrating its efficacy against bacterial virulence in vivo, with no toxicity effects. |
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| References | 1. Tibisay Guevara, et al. Sci Rep. 2019; 9: 4935. 2. Kataoka S, et al. FASEB J. 2014 Aug; 28(8):3564-78. 3. Kadowaki T, et al. Mol Pharmacol. 2004 Dec;66(6):1599-606. |
| Molecular Formula | C34H42N6O6 |
|---|---|
| Molecular Weight | 630.746 |