454473-31-5

454473-31-5 structure

Name: KYT-36
Chemical Name: KYT-36
CAS Number: 454473-31-5
Molecular Formula: C₃₄H₄₂N₆O₆
Molecular Weight: 630.746
Create Date: 2022-07-01 18:43:00
Modify Date: 2024-01-13 11:25:06
KYT-36 is a potent, selective, and bioavailable inhibitor of P. gingivalis virulence factor gingipain K (Kgp, lysine-gingipain), potently and selectively inhibits Kgp with Ki of 0.27 nM, respectively.KYT-36 consists of benzyloxycarbonyl (BOC), L-glutaminyl (GLN), methylphenylamino (MPA), L-lysinyl (LYS), and benzylcarbamoyl (BCA) moieties.KYT-36 strongly inhibited degradation of host proteins in culture supernatants and abolished thriving of P. gingivalis in cell cultures and in periodontal pockets in vivo.KYT-36 prevented Kgp-triggered vascular permeability in guinea pigs, i.e. demonstrating its efficacy against bacterial virulence in vivo, with no toxicity effects.

Name	KYT-36

Description	KYT-36 is a potent, selective, and bioavailable inhibitor of P. gingivalis virulence factor gingipain K (Kgp, lysine-gingipain), potently and selectively inhibits Kgp with Ki of 0.27 nM, respectively.KYT-36 consists of benzyloxycarbonyl (BOC), L-glutaminyl (GLN), methylphenylamino (MPA), L-lysinyl (LYS), and benzylcarbamoyl (BCA) moieties.KYT-36 strongly inhibited degradation of host proteins in culture supernatants and abolished thriving of P. gingivalis in cell cultures and in periodontal pockets in vivo.KYT-36 prevented Kgp-triggered vascular permeability in guinea pigs, i.e. demonstrating its efficacy against bacterial virulence in vivo, with no toxicity effects.
References	1. Tibisay Guevara, et al. Sci Rep. 2019; 9: 4935. 2. Kataoka S, et al. FASEB J. 2014 Aug; 28(8):3564-78. 3. Kadowaki T, et al. Mol Pharmacol. 2004 Dec;66(6):1599-606.

Molecular Formula	C₃₄H₄₂N₆O₆
Molecular Weight	630.746