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1808948-28-8

1808948-28-8 structure
1808948-28-8 structure
  • Name: (2S,3R)-LP99
  • Chemical Name: (2S,3R)-LP99
  • CAS Number: 1808948-28-8
  • Molecular Formula: C26H30ClN3O4S
  • Molecular Weight: 516.05
  • Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
  • Create Date: 2022-07-11 10:44:19
  • Modify Date: 2024-01-12 11:37:43
  • (2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1].

Name (2S,3R)-LP99
Description (2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1].
Related Catalog
Target

BRD7

BRD9:99 nM (Kd)

In Vitro (2S,3R)-LP99 (compound 60) (0-100 µM) inhibits the expression of IL6 in LPS-stimulated (100 ng/mL) THP-1 cells[1].
References

[1]. Clark PG, et al. LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Angew Chem Int Ed Engl. 2015 May 18;54(21):6217-21.

Molecular Formula C26H30ClN3O4S
Molecular Weight 516.05