1808948-28-8
1808948-28-8 structure
- Name: (2S,3R)-LP99
- Chemical Name: (2S,3R)-LP99
- CAS Number: 1808948-28-8
- Molecular Formula: C26H30ClN3O4S
- Molecular Weight: 516.05
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2022-07-11 10:44:19
- Modify Date: 2024-01-12 11:37:43
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(2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1].
| Name | (2S,3R)-LP99 |
|---|
| Description | (2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1]. |
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| Related Catalog | |
| Target |
BRD7 BRD9:99 nM (Kd) |
| In Vitro | (2S,3R)-LP99 (compound 60) (0-100 µM) inhibits the expression of IL6 in LPS-stimulated (100 ng/mL) THP-1 cells[1]. |
| References |
| Molecular Formula | C26H30ClN3O4S |
|---|---|
| Molecular Weight | 516.05 |