1946008-31-6

1946008-31-6 structure

Name: AChE/BuChE-IN-2
Chemical Name: AChE/BuChE-IN-2
CAS Number: 1946008-31-6
Molecular Formula: C₂₀H₁₈N₂O₂
Molecular Weight: 318.37
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2022-08-09 22:44:18
Modify Date: 2024-01-16 17:56:23
AChE/BuChE-IN-2 (Compound 5f) is an orally active AChE and BuChE inhibitor with IC50 values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows a non-competitive inhibition with AChE and shows potent self-induced β-amyloid (Aβ) aggregation inhibition with an IC50 of 62.52 μM. AChE/BuChE-IN-2 can cross the BBB[1].

Name	AChE/BuChE-IN-2

Description	AChE/BuChE-IN-2 (Compound 5f) is an orally active AChE and BuChE inhibitor with IC50 values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows a non-competitive inhibition with AChE and shows potent self-induced β-amyloid (Aβ) aggregation inhibition with an IC50 of 62.52 μM. AChE/BuChE-IN-2 can cross the BBB[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	IC50: 0.16 μM (BuChE), 0.72 μM (AChE), 62.52 μM (Aβ aggregation)[1]
In Vivo	AChE/BuChE-IN-2 (Compound 5f) (20 μmol/kg) significantly ameliorates the cognitive performances of scopolamine-treated ICR mice[1].
References	[1]. Luo W, et al. Synthesis, in vitro and in vivo biological evaluation of novel graveolinine derivatives as potential anti-Alzheimer agents. Bioorg Med Chem. 2020 Jan 1;28(1):115190.

Molecular Formula	C₂₀H₁₈N₂O₂
Molecular Weight	318.37