AChE/BuChE-IN-2
Modify Date: 2024-01-16 17:56:23
AChE/BuChE-IN-2 structure
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Common Name | AChE/BuChE-IN-2 | ||
|---|---|---|---|---|
| CAS Number | 1946008-31-6 | Molecular Weight | 318.37 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H18N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AChE/BuChE-IN-2AChE/BuChE-IN-2 (Compound 5f) is an orally active AChE and BuChE inhibitor with IC50 values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows a non-competitive inhibition with AChE and shows potent self-induced β-amyloid (Aβ) aggregation inhibition with an IC50 of 62.52 μM. AChE/BuChE-IN-2 can cross the BBB[1]. |
| Name | AChE/BuChE-IN-2 |
|---|
| Description | AChE/BuChE-IN-2 (Compound 5f) is an orally active AChE and BuChE inhibitor with IC50 values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows a non-competitive inhibition with AChE and shows potent self-induced β-amyloid (Aβ) aggregation inhibition with an IC50 of 62.52 μM. AChE/BuChE-IN-2 can cross the BBB[1]. |
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| Related Catalog | |
| Target |
IC50: 0.16 μM (BuChE), 0.72 μM (AChE), 62.52 μM (Aβ aggregation)[1] |
| In Vivo | AChE/BuChE-IN-2 (Compound 5f) (20 μmol/kg) significantly ameliorates the cognitive performances of scopolamine-treated ICR mice[1]. |
| References |
| Molecular Formula | C20H18N2O2 |
|---|---|
| Molecular Weight | 318.37 |