354815-43-3

354815-43-3 structure

Name: Androgen receptor antagonist 4
Chemical Name: Androgen receptor antagonist 4
CAS Number: 354815-43-3
Molecular Formula: C₂₂H₁₈ClN
Molecular Weight: 331.84
Catalog: Research Areas Cancer
Create Date: 2022-07-02 18:05:44
Modify Date: 2024-01-09 12:25:46
Androgen receptor antagonist 4 (Compound AT2) is an androgen receptor (AR) antagonist with an IC50 of 0.15 μM. Androgen receptor antagonist 4 efficiently antagonizes AR transcriptional activity, suppresses downstream target gene of AR, and blocks the DHT-induced AR nuclear translocation. Androgen receptor antagonist 4 shows anticancer activities[1].

Name	Androgen receptor antagonist 4

Description	Androgen receptor antagonist 4 (Compound AT2) is an androgen receptor (AR) antagonist with an IC50 of 0.15 μM. Androgen receptor antagonist 4 efficiently antagonizes AR transcriptional activity, suppresses downstream target gene of AR, and blocks the DHT-induced AR nuclear translocation. Androgen receptor antagonist 4 shows anticancer activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Androgen Receptor
Target	IC50: 0.15 μM (Androgen receptor)[1]
References	[1]. Tang Q, et al. Novel androgen receptor antagonist identified by structure-based virtual screening, structural optimization, and biological evaluation. Eur J Med Chem. 2020 Apr 15;192:112156.

Molecular Formula	C₂₂H₁₈ClN
Molecular Weight	331.84