2395009-13-7
2395009-13-7 structure
- Name: Anticancer agent 48
- Chemical Name: Anticancer agent 48
- CAS Number: 2395009-13-7
- Molecular Formula: C26H25N3O4
- Molecular Weight: 443.49
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
- Create Date: 2022-06-26 19:00:31
- Modify Date: 2024-01-05 12:56:22
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Anticancer agent 48 (compound 48) is a broad spectrum anticancer agent. Anticancer agent 48 inhibits tubulin polymerization. Anticancer agent 48 shows antiproliferative activity. Anticancer agent 48 shows antitumor activity in vivo. Anticancer agent 48 has the potential for the research of solid and hematological tumors[1].
| Name | Anticancer agent 48 |
|---|
| Description | Anticancer agent 48 (compound 48) is a broad spectrum anticancer agent. Anticancer agent 48 inhibits tubulin polymerization. Anticancer agent 48 shows antiproliferative activity. Anticancer agent 48 shows antitumor activity in vivo. Anticancer agent 48 has the potential for the research of solid and hematological tumors[1]. |
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| Related Catalog | |
| In Vitro | Anticancer agent 48 (compound 48) inhibits tubulin polymerization and MCF-7 cancer cell growth with IC50s of 0.47 µM and 14 nM, respectively[1]. Anticancer agent 48 shows antiproliferative activity with IC50s of 8, 10, 12, 14, 16 nM for KU812, LAMA84-S, LAMA84-R, KBM5-WT, KBM5-T315I cells, respectively[1]. Anticancer agent 48 shows growth inhibition with IC50s of 12, 31, 37, 221, 56, 27, 51, 48, 28, 12 nM for U343G, U87MG, T98G, SK-N-BE, SK-N-BE(2)-C, HT29, HCT116, SW480, SW620, T24 cell, respectively[1]. |
| In Vivo | Anticancer agent 48 (20 mg/kg; i.p.; every 2 days for 40 days) shows antitumor effects[1]. Animal Model: 8 week-old female BALB/Cnu/nu mice (EZ-2 or T24 cells)[1] Dosage: 20 mg/kg Administration: I.p.; every 2 days for 40 days Result: Significantly inhibited cancer cell proliferation, in vivo tumorigenesis, and tumor angiogenesis. |
| References |
| Molecular Formula | C26H25N3O4 |
|---|---|
| Molecular Weight | 443.49 |