1186049-44-4

1186049-44-4 structure

Name: DDO-02005
Chemical Name: DDO-02005
CAS Number: 1186049-44-4
Molecular Formula: C₂₁H₂₇Cl₂N₃O₂
Molecular Weight: 424.36
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2022-07-01 14:04:26
Modify Date: 2024-01-09 11:56:57
DDO-02005 is a potent Kv1.5 potassium channel inhibitor with an IC50 value of 0.72 μM. DDO-02005 has good anti-atrial fibrillation (AF) effect in CaCl2-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine[1].

Name	DDO-02005

Description	DDO-02005 is a potent Kv1.5 potassium channel inhibitor with an IC50 value of 0.72 μM. DDO-02005 has good anti-atrial fibrillation (AF) effect in CaCl2-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 0.72 μM (Kv1.5 potassium channel)[1]
In Vivo	DDO-02005 (0.1, 1, 3, 9 mg/kg; IV, single dosage) effectively combat the arrhythmogenic toxicity of aconitine in rats[1]. Pharmacokinetic Parameters of DDO-02005 in Sprague-Dawley rats[1]. IV (1 mg/kg) PO (1.25 mg/kg) t1/2 (h) 3.23 ± 1.07 6.25 ± 2.40 Cmax (μg/L) 90.23 ± 28.83 1.27 ± 0.40 AUC0-t (μg/L·h) 178.42 ± 39.33 4.41 ± 0.69 CL (L/h/kg) 5.83 ± 1.44 36.51 ± 2.54
References	[1]. Zhao L, et al. Design, synthesis, and biological evaluation of arylmethylpiperidines as Kv1.5 potassium channel inhibitors. J Enzyme Inhib Med Chem. 2022;37(1):462-471.

Molecular Formula	C₂₁H₂₇Cl₂N₃O₂
Molecular Weight	424.36