1239589-91-3

1239589-91-3 structure

Name: LSD1-IN-20
Chemical Name: LSD1-IN-20
CAS Number: 1239589-91-3
Molecular Formula: C₂₇H₃₈N₆O₂
Molecular Weight: 478.63
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2022-07-01 11:46:50
Modify Date: 2024-01-14 18:29:22
LSD1-IN-20 (compound 1) is a potent dual non-covalent LSD1/G9a inhibitor, with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.51 and 1.60 μM, respectively[1].

Name	LSD1-IN-20

Description	LSD1-IN-20 (compound 1) is a potent dual non-covalent LSD1/G9a inhibitor, with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.51 and 1.60 μM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase Signaling Pathways >> Epigenetics >> Histone Demethylase
Target	Ki of 0.440 ± 0.05 μM (LSD1), 0.68 ± 0.02 μM (G9a)[1]
References	[1]. Menna M, et al. Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur J Med Chem. 2022 Jul 5;237:114410.

Molecular Formula	C₂₇H₃₈N₆O₂
Molecular Weight	478.63