LSD1-IN-20

Modify Date: 2024-01-14 18:29:22

LSD1-IN-20 structure	Common Name	LSD1-IN-20
	CAS Number	1239589-91-3	Molecular Weight	478.63
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₈N₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of LSD1-IN-20

LSD1-IN-20 (compound 1) is a potent dual non-covalent LSD1/G9a inhibitor, with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.51 and 1.60 μM, respectively[1].

Name	LSD1-IN-20

Description	LSD1-IN-20 (compound 1) is a potent dual non-covalent LSD1/G9a inhibitor, with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.51 and 1.60 μM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase Signaling Pathways >> Epigenetics >> Histone Demethylase
Target	Ki of 0.440 ± 0.05 μM (LSD1), 0.68 ± 0.02 μM (G9a)[1]
References	[1]. Menna M, et al. Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur J Med Chem. 2022 Jul 5;237:114410.

Molecular Formula	C₂₇H₃₈N₆O₂
Molecular Weight	478.63

LSD1-IN-20

Use of LSD1-IN-20

Names

LSD1-IN-20 Biological Activity

Chemical & Physical Properties