1446324-02-2

1446324-02-2 structure

Name: MET kinase-IN-3
Chemical Name: MET kinase-IN-3
CAS Number: 1446324-02-2
Molecular Formula: C₂₅H₁₆ClF₂N₅O₂
Molecular Weight: 491.88
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Met/HGFR
Create Date: 2022-07-01 16:57:20
Modify Date: 2025-08-26 23:11:55
MET kinase-IN-3 (compound 8) is an orally active and potent MET inhibitor, with an IC50 of 9.8 nM. MET kinase-IN-3 shows good and broad-spectrum antiproliferative activity against cancer cell lines[1].

Name	MET kinase-IN-3

Description	MET kinase-IN-3 (compound 8) is an orally active and potent MET inhibitor, with an IC50 of 9.8 nM. MET kinase-IN-3 shows good and broad-spectrum antiproliferative activity against cancer cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
Target	MET:9.8 nM (IC50) VEGFR2:68 nM (IC50)
References	[1]. Wang MS, et al. Synthesis and biological evaluation of new MET inhibitors with 1,6-naphthyridinone scaffold. Eur J Med Chem. 2020 Jan 1;185:111803.

Molecular Formula	C₂₅H₁₆ClF₂N₅O₂
Molecular Weight	491.88