MET kinase-IN-3

Modify Date: 2025-08-26 23:11:55

MET kinase-IN-3 structure	Common Name	MET kinase-IN-3
	CAS Number	1446324-02-2	Molecular Weight	491.88
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₁₆ClF₂N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MET kinase-IN-3

MET kinase-IN-3 (compound 8) is an orally active and potent MET inhibitor, with an IC50 of 9.8 nM. MET kinase-IN-3 shows good and broad-spectrum antiproliferative activity against cancer cell lines[1].

Name	MET kinase-IN-3

Description	MET kinase-IN-3 (compound 8) is an orally active and potent MET inhibitor, with an IC50 of 9.8 nM. MET kinase-IN-3 shows good and broad-spectrum antiproliferative activity against cancer cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
Target	MET:9.8 nM (IC50) VEGFR2:68 nM (IC50)
References	[1]. Wang MS, et al. Synthesis and biological evaluation of new MET inhibitors with 1,6-naphthyridinone scaffold. Eur J Med Chem. 2020 Jan 1;185:111803.

Molecular Formula	C₂₅H₁₆ClF₂N₅O₂
Molecular Weight	491.88

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