2272894-14-9

2272894-14-9 structure

Name: PI3Kα-IN-6
Chemical Name: PI3Kα-IN-6
CAS Number: 2272894-14-9
Molecular Formula: C₁₆H₁₅IN₂OS
Molecular Weight: 410.27
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-06-26 12:23:28
Modify Date: 2024-04-04 16:43:35
PI3Kα-IN-6 (Compound 5b) is a PI3Kα inhibitor. PI3Kα-IN-6 exhibits anticancer potential and no toxicity in normal cells. PI3Kα-IN-6 increases generation of ROS, reduces mitochondrial membrane potential (MMP) and induces apoptosis[1].

Name	PI3Kα-IN-6

Description	PI3Kα-IN-6 (Compound 5b) is a PI3Kα inhibitor. PI3Kα-IN-6 exhibits anticancer potential and no toxicity in normal cells. PI3Kα-IN-6 increases generation of ROS, reduces mitochondrial membrane potential (MMP) and induces apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS
Target	PI3Kα
In Vitro	PI3Kα-IN-6 (Compound 5b) shows cell growth inhibition with IC50 values of 3.5, 8.7, 8.9, 26.5, 89.9, 61.1 and 112.02 against HCT-116, A-549, MiaPaca-2, MCF-7, MDA-MB-231, PC-3 and HEK-293 cells, respectively[1].
References	[1]. Singh D, et al. Synthesis of 3-N-/O-/S-methyl-imidazo[1,2-a] pyridine derivatives for caspase-3 mediated apoptosis induced anticancer activity.

Molecular Formula	C₁₆H₁₅IN₂OS
Molecular Weight	410.27