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2417098-53-2

2417098-53-2 structure

2417098-53-2 structure

Name: PI3Kα-IN-7
Chemical Name: PI3Kα-IN-7
CAS Number: 2417098-53-2
Molecular Formula: C₁₇H₂₂N₈O₂S
Molecular Weight: 402.47
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-18 17:54:23
Modify Date: 2025-09-28 17:54:38
PI3Kα-IN-7 (Compound A12) is a potent PI3Kα inhibitor. PI3Kα-IN-7 also inhibits PI3Kβ. PI3Kα-IN-7 decreases cancer cells mitochondrial membrane potential and induces apoptosis[1].

Name	PI3Kα-IN-7

Description	PI3Kα-IN-7 (Compound A12) is a potent PI3Kα inhibitor. PI3Kα-IN-7 also inhibits PI3Kβ. PI3Kα-IN-7 decreases cancer cells mitochondrial membrane potential and induces apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	PI3Kα PI3Kβ
In Vitro	PI3Kα-IN-7 (Compound A12) shows potent antitumor activities against HCT116, PC-3, MCF-7, A549 and MDA-MB-231 cell lines with IC50 values of 3.24 μM, 14.37 μM, 7.39 μM, 7.10 μM, and 16.85 μM, respectively[1].
References	[1]. Ye T, et al. Design, synthesis and biological evaluation of novel 2,4-bismorpholinothieno[3,2-d]pyrimidine and 2-morpholinothieno[3,2-d]pyrimidinone derivatives as potent antitumor agents. Bioorg Chem. 2020 Jun;99:103796.

Molecular Formula	C₁₇H₂₂N₈O₂S
Molecular Weight	402.47

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