2245820-70-4

2245820-70-4 structure

2245820-70-4 structure

Name: RIPK2-IN-1
Chemical Name: RIPK2-IN-1
CAS Number: 2245820-70-4
Molecular Formula: C₂₃H₂₇N₅O₃S
Molecular Weight: 453.56
Catalog: Signaling Pathways Apoptosis RIP kinase
Create Date: 2022-07-11 08:45:51
Modify Date: 2024-01-14 13:14:02
RIPK2-IN-1 (compound 18f) is a potent RIPK2 inhibitor with an IC50 of 51 nM. RIPK2-IN-1 inhibits ALK2 with an IC50 of 5 nM. RIPK2-IN-1 has an IC50 of 390 nM on RIPK2/NOD2 in cell assay[1].

Name	RIPK2-IN-1

Description	RIPK2-IN-1 (compound 18f) is a potent RIPK2 inhibitor with an IC50 of 51 nM. RIPK2-IN-1 inhibits ALK2 with an IC50 of 5 nM. RIPK2-IN-1 has an IC50 of 390 nM on RIPK2/NOD2 in cell assay[1].
Related Catalog	Signaling Pathways >> Apoptosis >> RIP kinase Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK Research Areas >> Inflammation/Immunology
References	[1]. Chalada Suebsuwong, et al. Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold. Eur J Med Chem. 2020 Aug 15;200:112417.

Molecular Formula	C₂₃H₂₇N₅O₃S
Molecular Weight	453.56