1580-42-3

1580-42-3 structure
1580-42-3 structure
  • Name: SARS-CoV-2-IN-15
  • Chemical Name: SARS-CoV-2-IN-15
  • CAS Number: 1580-42-3
  • Molecular Formula: C14H9ClF3NO2
  • Molecular Weight: 315.67
  • Catalog: Signaling Pathways Anti-infection SARS-CoV
  • Create Date: 2022-07-11 22:41:58
  • Modify Date: 2024-04-06 21:31:16
  • SARS-CoV-2-IN-15 (compound 11) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.49 μM. SARS-CoV-2-IN-15 is a niclosamide analogue. SARS-CoV-2-IN-15 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].

Name SARS-CoV-2-IN-15
Description SARS-CoV-2-IN-15 (compound 11) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.49 μM. SARS-CoV-2-IN-15 is a niclosamide analogue. SARS-CoV-2-IN-15 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].
Related Catalog
References

[1]. Juang YP, et al. Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2. Eur J Med Chem. 2022 May 5;235:114295.

Molecular Formula C14H9ClF3NO2
Molecular Weight 315.67
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