SARS-CoV-2-IN-15

Modify Date: 2024-04-06 21:31:16

SARS-CoV-2-IN-15 Structure
SARS-CoV-2-IN-15 structure
Common Name SARS-CoV-2-IN-15
CAS Number 1580-42-3 Molecular Weight 315.67
Density N/A Boiling Point N/A
Molecular Formula C14H9ClF3NO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SARS-CoV-2-IN-15


SARS-CoV-2-IN-15 (compound 11) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.49 μM. SARS-CoV-2-IN-15 is a niclosamide analogue. SARS-CoV-2-IN-15 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].

 Names

Name SARS-CoV-2-IN-15

 SARS-CoV-2-IN-15 Biological Activity

Description SARS-CoV-2-IN-15 (compound 11) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.49 μM. SARS-CoV-2-IN-15 is a niclosamide analogue. SARS-CoV-2-IN-15 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].
Related Catalog
References

[1]. Juang YP, et al. Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2. Eur J Med Chem. 2022 May 5;235:114295.

 Chemical & Physical Properties

Molecular Formula C14H9ClF3NO2
Molecular Weight 315.67
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