Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SHP2 protein degrader-2
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

2740582-16-3

2740582-16-3 structure

2740582-16-3 structure

Name: SHP2 protein degrader-2
Chemical Name: SHP2 protein degrader-2
CAS Number: 2740582-16-3
Molecular Formula: C₅₆H₇₉ClN₁₂O₆S₂
Molecular Weight: 1115.89
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2022-07-15 18:04:20
Modify Date: 2024-01-08 11:04:14
SHP2 protein degrader-2 (SHP2-D26) is a SHP2 protein PROTAC degrader. SHP2 protein degrader-2 reduces expression level of SHP2 in various cancer cells[1].

Name	SHP2 protein degrader-2

Description	SHP2 protein degrader-2 (SHP2-D26) is a SHP2 protein PROTAC degrader. SHP2 protein degrader-2 reduces expression level of SHP2 in various cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Signaling Pathways >> PROTAC >> PROTAC
In Vitro	SHP2 protein degrader-2 (SHP2-D26) achieves excellent degradation of SHP2 with the DC50 (the concentration where 50% of the protein has been degraded) values of 2.6 nM and 6.0 nM for MV4;11 and KYSE520 cells, respectively[1].
References	[1]. Song Y, et al. Strategies Targeting Protein Tyrosine Phosphatase SHP2 for Cancer Therapy. J Med Chem. 2022 Feb 24;65(4):3066-3079.

Molecular Formula	C₅₆H₇₉ClN₁₂O₆S₂
Molecular Weight	1115.89

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.