SHP2 protein degrader-2

Modify Date: 2025-08-25 10:45:09

SHP2 protein degrader-2 structure	Common Name	SHP2 protein degrader-2
	CAS Number	2740582-16-3	Molecular Weight	1115.89
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₆H₇₉ClN₁₂O₆S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SHP2 protein degrader-2

SHP2 protein degrader-2 (SHP2-D26) is a SHP2 protein PROTAC degrader. SHP2 protein degrader-2 reduces expression level of SHP2 in various cancer cells[1].

Name	SHP2 protein degrader-2

Description	SHP2 protein degrader-2 (SHP2-D26) is a SHP2 protein PROTAC degrader. SHP2 protein degrader-2 reduces expression level of SHP2 in various cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Signaling Pathways >> PROTAC >> PROTAC
In Vitro	SHP2 protein degrader-2 (SHP2-D26) achieves excellent degradation of SHP2 with the DC50 (the concentration where 50% of the protein has been degraded) values of 2.6 nM and 6.0 nM for MV4;11 and KYSE520 cells, respectively[1].
References	[1]. Song Y, et al. Strategies Targeting Protein Tyrosine Phosphatase SHP2 for Cancer Therapy. J Med Chem. 2022 Feb 24;65(4):3066-3079.

Molecular Formula	C₅₆H₇₉ClN₁₂O₆S₂
Molecular Weight	1115.89

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