2523016-96-6

2523016-96-6 structure

Name: SK-575
Chemical Name: SK-575
CAS Number: 2523016-96-6
Molecular Formula: C₄₇H₅₃FN₈O₈
Molecular Weight: 876.97
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2022-07-11 14:36:06
Modify Date: 2024-01-02 19:47:44
SK-575 is a highly potent and specific proteolysis-targeting chimera (PROTAC) degrader of PARP1. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations. SK-575 inhibits cell growth in MDA-MB-436 and Capan-1 cells, with IC50 values of 19 ± 6 nM and 56 ± 12 nM, respectively[1].

Name	SK-575

Description	SK-575 is a highly potent and specific proteolysis-targeting chimera (PROTAC) degrader of PARP1. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations. SK-575 inhibits cell growth in MDA-MB-436 and Capan-1 cells, with IC50 values of 19 ± 6 nM and 56 ± 12 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	PARP1
In Vivo	SK-575 achieves sufficient exposure in plasma for over 24 h and effectively induces PARP1 degradation in the SW620 xenograft tumor tissue with the effect persisting for >24 h[1]. SK-575 (mice bearing BRCA2-mutated Capan-1 xenografts, 25 and 50 mg/kg, IP, once daily for 5 days) significantly inhibits the tumor growth in vivo as a single-agent in HR-deficient xenograft models[1].
References	[1]. Cao C, et al. Discovery of SK-575 as a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers. J Med Chem. 2020 Oct 8;63(19):11012-11033.

Molecular Formula	C₄₇H₅₃FN₈O₈
Molecular Weight	876.97