2439177-97-4

2439177-97-4 structure

Name: ALDH1A1-IN-3
Chemical Name: ALDH1A1-IN-3
CAS Number: 2439177-97-4
Molecular Formula: C₃₁H₃₆F₃N₅O₄
Molecular Weight: 599.64
Catalog: Signaling Pathways Metabolic Enzyme/Protease Aldehyde Dehydrogenase (ALDH)
Create Date: 2022-08-16 10:37:25
Modify Date: 2026-07-27 17:58:04
ALDH1A1-IN-3 (compound 57) is an excellent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with an IC50 value of 0.379 μM. ALDH1A1-IN-3 can effectively improve glucose consumption in HepG2 cells. ALDH1A1-IN-3 can be used for researching glucose metabolism improvement[1].

Name	ALDH1A1-IN-3
Synonyms	1-Piperazinropanamide, 4-[4-(1-methylethyl)benzoyl]-N-(1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)-N-[[3-(trifluoromethyl)phenyl]methyl]

Description	ALDH1A1-IN-3 (compound 57) is an excellent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with an IC50 value of 0.379 μM. ALDH1A1-IN-3 can effectively improve glucose consumption in HepG2 cells. ALDH1A1-IN-3 can be used for researching glucose metabolism improvement[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aldehyde Dehydrogenase (ALDH) Research Areas >> Metabolic Disease
Target	IC50: 0.379 μM (ALDH1A1)[1]
References	[1]. Ma Z, et al. Design, synthesis of 1,3-dimethylpyrimidine-2,4-diones as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity. Bioorg Chem. 2020 Aug;101:103971.

Molecular Formula	C₃₁H₃₆F₃N₅O₄
Molecular Weight	599.64