2470019-41-9

2470019-41-9 structure

Name: Aldose reductase-IN-6
Chemical Name: Aldose reductase-IN-6
CAS Number: 2470019-41-9
Molecular Formula: C₂₀H₁₆N₄O₂S
Molecular Weight: 376.43
Catalog: Signaling Pathways Metabolic Enzyme/Protease Aldose Reductase
Create Date: 2022-08-17 20:44:19
Modify Date: 2026-08-02 14:07:49
Aldose reductase-IN-6 (Compound 3) is a competitive aldose reductase (AR) inhibitor with an IC50 of 3.164 μM and a Ki of 0.018 μM. Aldose reductase-IN-6 exhibits no cytotoxicity against healthy cells[1].

Name	Aldose reductase-IN-6
Synonyms	Benzonitrile, 4-[2-[2-[(3,4-dihydro-2H-1,5-benzodioxin-7-yl)methylene]hydrazinyl]-4-thiazolyl]

Description	Aldose reductase-IN-6 (Compound 3) is a competitive aldose reductase (AR) inhibitor with an IC50 of 3.164 μM and a Ki of 0.018 μM. Aldose reductase-IN-6 exhibits no cytotoxicity against healthy cells[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase Research Areas >> Metabolic Disease
Target	IC50: 3.164 μM (Aldose Reductase)[1]
References	[1]. Sever B, et al. Design, synthesis, in vitro and in silico investigation of aldose reductase inhibitory effects of new thiazole-based compounds. Bioorg Chem. 2020 Sep;102:104110.

Molecular Formula	C₂₀H₁₆N₄O₂S
Molecular Weight	376.43