2419233-57-9

2419233-57-9 structure

Name: ALR1/2-IN-1
Chemical Name: ALR1/2-IN-1
CAS Number: 2419233-57-9
Molecular Formula: C₁₈H₁₈N₄O₅S₂
Molecular Weight: 434.49
Catalog: Signaling Pathways Metabolic Enzyme/Protease Aldose Reductase
Create Date: 2022-08-12 20:03:58
Modify Date: 2026-07-08 21:44:36
ALR1/2-IN-1 (Compound 6e) is an aldehyde reductase (ALR1) and aldose reductase (ALR2) inhibitor with IC50 values of 3.26 μM and 3.06 μM against ALR1 and ALR2, respectively. ALR1/2-IN-1 shows anticancer activity[1].

Name	ALR1/2-IN-1
Synonyms	Acetamide, N-(2-methoxyphenyl)-2-[[5-[2-[(methylsulfonyl)amino]phenyl]-1,3,4-oxadiazol-2-yl]thio] A1/2-IN-1

Description	ALR1/2-IN-1 (Compound 6e) is an aldehyde reductase (ALR1) and aldose reductase (ALR2) inhibitor with IC50 values of 3.26 μM and 3.06 μM against ALR1 and ALR2, respectively. ALR1/2-IN-1 shows anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase
Target	IC50: 3.06 μM (ALR2), 3.26 μM (ALR1)[1]
In Vitro	ALR1/2-IN-1 (Compound 6e) (100 µM) shows cytotoxic potential with 32.9 ± 3.26% inhibition against cervical carcinoma cells HeLa[1].
References	[1]. Javid N, et al. Exploiting oxadiazole-sulfonamide hybrids as new structural leads to combat diabetic complications via aldose reductase inhibition. Bioorg Chem. 2020 Jun;99:103852.

Molecular Formula	C₁₈H₁₈N₄O₅S₂
Molecular Weight	434.49