ALR1/2-IN-1

Modify Date: 2024-01-09 11:01:37

ALR1/2-IN-1 structure	Common Name	ALR1/2-IN-1
	CAS Number	2419233-57-9	Molecular Weight	434.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₈N₄O₅S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ALR1/2-IN-1

ALR1/2-IN-1 (Compound 6e) is an aldehyde reductase (ALR1) and aldose reductase (ALR2) inhibitor with IC50 values of 3.26 μM and 3.06 μM against ALR1 and ALR2, respectively. ALR1/2-IN-1 shows anticancer activity[1].

Name	ALR1/2-IN-1

Description	ALR1/2-IN-1 (Compound 6e) is an aldehyde reductase (ALR1) and aldose reductase (ALR2) inhibitor with IC50 values of 3.26 μM and 3.06 μM against ALR1 and ALR2, respectively. ALR1/2-IN-1 shows anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase
Target	IC50: 3.06 μM (ALR2), 3.26 μM (ALR1)[1]
In Vitro	ALR1/2-IN-1 (Compound 6e) (100 µM) shows cytotoxic potential with 32.9 ± 3.26% inhibition against cervical carcinoma cells HeLa[1].
References	[1]. Javid N, et al. Exploiting oxadiazole-sulfonamide hybrids as new structural leads to combat diabetic complications via aldose reductase inhibition. Bioorg Chem. 2020 Jun;99:103852.

Molecular Formula	C₁₈H₁₈N₄O₅S₂
Molecular Weight	434.49

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