1411867-74-7

1411867-74-7 structure

Name: Asenapine citrate
Chemical Name: Asenapine citrate
CAS Number: 1411867-74-7
Molecular Formula: C₂₃H₂₄ClNO₈
Molecular Weight: 477.89
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2022-08-16 11:15:40
Modify Date: 2024-01-11 12:59:15
Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine citrate can be used in the research of schizophrenia and bipolar disorder[1][2].

Name	Asenapine citrate

Description	Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine citrate can be used in the research of schizophrenia and bipolar disorder[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	5-HT1A Receptor:8.6 (pKi) 5-HT1B Receptor:8.4 (pKi) 5-HT2A Receptor:10.2 (pKi) 5-HT2B Receptor:9.8 (pKi) 5-HT2C Receptor:10.5 (pKi) 5-HT5 Receptor:8.8 (pKi) 5-HT6 Receptor:9.6 (pKi) 5-HT7 Receptor:9.9 (pKi) α1-adrenergic receptor:8.9 (pKi) Alpha-2A adrenergic receptor:8.9 (pKi) Alpha-2B adrenergic receptor:9.5 (pKi) Alpha-2C adrenergic receptor:8.9 (pKi) D1 Receptor:8.9 (pKi) D2 Receptor:8.9 (pKi) D3 Receptor:9.4 (pKi) D4 Receptor:9.0 (pKi) H1 Receptor:9.0 (pKi) H2 Receptor:8.2 (pKi)
In Vivo	Asenapine (0.05-0.2 mg/kg; s.c.) induces a dose-dependent suppression of conditioned avoidance response (CAR) and does not induce catalepsy[2].
References	[1]. M Shahid, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23(1):65-73. [2]. Olivia Frånberg, et al. Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia. Psychopharmacology (Berl). 2008 Feb;196(3):417-29.

Molecular Formula	C₂₃H₂₄ClNO₈
Molecular Weight	477.89

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