2231424-62-5

2231424-62-5 structure

Name: Axl-IN-8
Chemical Name: Axl-IN-8
CAS Number: 2231424-62-5
Molecular Formula: C₃₁H₂₉FN₆O₃
Molecular Weight: 552.60
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Met/HGFR
Create Date: 2022-08-05 12:53:29
Modify Date: 2024-01-03 01:38:31
Axl-IN-8 (NO.1) is a potent AXL inhibitor, with an IC50 of <1 nM. Axl-IN-8 also inhibits c-MET, with an IC50 of 1-10 nM. Axl-IN-8 shows anti-proliferative activity against BaF3/TEL-AXL, MKN45, and EBC-1 cells, with IC50 values of <10, 226.6 and 120.3 nM, respectively[1].

Name	Axl-IN-8

Description	Axl-IN-8 (NO.1) is a potent AXL inhibitor, with an IC50 of <1 nM. Axl-IN-8 also inhibits c-MET, with an IC50 of 1-10 nM. Axl-IN-8 shows anti-proliferative activity against BaF3/TEL-AXL, MKN45, and EBC-1 cells, with IC50 values of <10, 226.6 and 120.3 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> TAM Receptor Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
Target	c-Met:1-10 nM (IC50)
References	[1]. Duan Wenhu, et al. Compound having axl inhibitory activity, preparation method therefor and use thereof. WO2018121228A1.

Molecular Formula	C₃₁H₂₉FN₆O₃
Molecular Weight	552.60