2231424-62-5

2231424-62-5 structure
2231424-62-5 structure
  • Name: Axl-IN-8
  • Chemical Name: Axl-IN-8
  • CAS Number: 2231424-62-5
  • Molecular Formula: C31H29FN6O3
  • Molecular Weight: 552.60
  • Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Met/HGFR
  • Create Date: 2022-08-05 12:53:29
  • Modify Date: 2024-01-03 01:38:31
  • Axl-IN-8 (NO.1) is a potent AXL inhibitor, with an IC50 of <1 nM. Axl-IN-8 also inhibits c-MET, with an IC50 of 1-10 nM. Axl-IN-8 shows anti-proliferative activity against BaF3/TEL-AXL, MKN45, and EBC-1 cells, with IC50 values of <10, 226.6 and 120.3 nM, respectively[1].

Name Axl-IN-8
Description Axl-IN-8 (NO.1) is a potent AXL inhibitor, with an IC50 of <1 nM. Axl-IN-8 also inhibits c-MET, with an IC50 of 1-10 nM. Axl-IN-8 shows anti-proliferative activity against BaF3/TEL-AXL, MKN45, and EBC-1 cells, with IC50 values of <10, 226.6 and 120.3 nM, respectively[1].
Related Catalog
Target

c-Met:1-10 nM (IC50)

References

[1]. Duan Wenhu, et al. Compound having axl inhibitory activity, preparation method therefor and use thereof. WO2018121228A1.

Molecular Formula C31H29FN6O3
Molecular Weight 552.60
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