2417977-65-0

2417977-65-0 structure

Name: Aβ-IN-5
Chemical Name: Aβ-IN-5
CAS Number: 2417977-65-0
Molecular Formula: C₂₁H₂₀N₂O₃
Molecular Weight: 348.40
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2022-08-15 13:04:43
Modify Date: 2024-01-11 22:51:21
Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor. Aβ-IN-5 also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Aβ-IN-5 shows excellent neuroprotective effects and low neurotoxicity[1].

Name	Aβ-IN-5

Description	Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor. Aβ-IN-5 also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Aβ-IN-5 shows excellent neuroprotective effects and low neurotoxicity[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	IC50: 1.32 μM (BuChE), 21.29 μM (AChE)[1]
In Vitro	Aβ-IN-5 (Compound e12) (25 μM) exhibits significant inhibition of Aβ aggregation with an inhibitory rate of 72%[1].
In Vivo	Aβ-IN-5 (Compound e12) (15 mg/kg; p.o.) restores learning and memory function and exhibits no acute toxicity in vivo[1].
References	[1]. Liao Q, et al. Design, synthesis and biological evaluation of novel carboline-cinnamic acid hybrids as multifunctional agents for treatment of Alzheimer's disease. Bioorg Chem. 2020 Jun;99:103844.

Molecular Formula	C₂₁H₂₀N₂O₃
Molecular Weight	348.40