Aβ-IN-5

Modify Date: 2024-01-11 22:51:21

Aβ-IN-5 structure	Common Name	Aβ-IN-5
	CAS Number	2417977-65-0	Molecular Weight	348.40
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₀N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Aβ-IN-5

Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor. Aβ-IN-5 also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Aβ-IN-5 shows excellent neuroprotective effects and low neurotoxicity[1].

Name	Aβ-IN-5

Description	Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor. Aβ-IN-5 also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Aβ-IN-5 shows excellent neuroprotective effects and low neurotoxicity[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	IC50: 1.32 μM (BuChE), 21.29 μM (AChE)[1]
In Vitro	Aβ-IN-5 (Compound e12) (25 μM) exhibits significant inhibition of Aβ aggregation with an inhibitory rate of 72%[1].
In Vivo	Aβ-IN-5 (Compound e12) (15 mg/kg; p.o.) restores learning and memory function and exhibits no acute toxicity in vivo[1].
References	[1]. Liao Q, et al. Design, synthesis and biological evaluation of novel carboline-cinnamic acid hybrids as multifunctional agents for treatment of Alzheimer's disease. Bioorg Chem. 2020 Jun;99:103844.

Molecular Formula	C₂₁H₂₀N₂O₃
Molecular Weight	348.40

Aβ-IN-5

Use of Aβ-IN-5

Names

Aβ-IN-5 Biological Activity

Chemical & Physical Properties