783324-98-1

783324-98-1 structure

Name: BOLD-100
Chemical Name: BOLD-100
CAS Number: 783324-98-1
Molecular Formula: C₁₄H₁₂Cl₄N₄Ru
Molecular Weight: 479.15
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2022-08-16 18:41:54
Modify Date: 2024-01-13 17:18:54
BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution[1].

Name	BOLD-100

Description	BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Target	GRP78, Autophagy[1]
References	[1]. Baier D, et al. The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation. Pharmaceutics. 2022;14(2):238. Published 2022 Jan 20.

Molecular Formula	C₁₄H₁₂Cl₄N₄Ru
Molecular Weight	479.15