BOLD-100

Modify Date: 2024-01-13 17:18:54

BOLD-100 Structure
BOLD-100 structure
Common Name BOLD-100
CAS Number 783324-98-1 Molecular Weight 479.15
Density N/A Boiling Point N/A
Molecular Formula C14H12Cl4N4Ru Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BOLD-100


BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution[1].

 Names

Name BOLD-100

 BOLD-100 Biological Activity

Description BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution[1].
Related Catalog
Target

GRP78, Autophagy[1]

References

[1]. Baier D, et al. The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation. Pharmaceutics. 2022;14(2):238. Published 2022 Jan 20.

 Chemical & Physical Properties

Molecular Formula C14H12Cl4N4Ru
Molecular Weight 479.15
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