252188-71-9
252188-71-9 structure
- Name: Ceftobiprole medocaril sodium
- Chemical Name: Ceftobiprole medocaril sodium
- CAS Number: 252188-71-9
- Molecular Formula: C26H25N8NaO11S2
- Molecular Weight: 712.64
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2022-08-22 21:12:58
- Modify Date: 2024-01-22 17:44:29
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Ceftobiprole medocaril (BAL5788) sodium is the parenteral prodrug of Ceftobiprole (HY-112579). Ceftobiprole is a parenteral pyrrolidinone cephalosporin. Ceftobiprole is a broad-spectrum cephalosporin with high levels of in vitro activity against methicillin- (MRSA) and vancomycin-resistant staphylococci (VRSA) and penicillin-resistant streptococci. Ceftobiprole also inhibits gram-positive and gram-negative pathogens[1][2].
| Name | Ceftobiprole medocaril sodium |
|---|
| Description | Ceftobiprole medocaril (BAL5788) sodium is the parenteral prodrug of Ceftobiprole (HY-112579). Ceftobiprole is a parenteral pyrrolidinone cephalosporin. Ceftobiprole is a broad-spectrum cephalosporin with high levels of in vitro activity against methicillin- (MRSA) and vancomycin-resistant staphylococci (VRSA) and penicillin-resistant streptococci. Ceftobiprole also inhibits gram-positive and gram-negative pathogens[1][2]. |
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| Related Catalog | |
| In Vivo | Ceftobiprole medocaril (s.c.; 3 × q12h; total daily doses of BAL9141 equivalents, 2.1, 4.2, or 8.4 mg/kg) causes ten-day cumulative survival rates ranged from 57 to 100% for female Swiss albino mice (body weight, 20 to 22 g) infected Penr Cros Ctxs strain P-15986[1]. Ceftobiprole medocaril (10, 40, 160 mg/kg; single dose; sc) has T1/2s from 20 min to 31 min, as the dose rose from 40 mg/kg to 160 mg/kg. The AUC/dose values for the escalating single doses ranges from 0.585 to 1.33, and the Cmax/dose values decreases from 1.08 to 0.90 in neutropenic thigh-infected mice[2]. |
| References |
| Molecular Formula | C26H25N8NaO11S2 |
|---|---|
| Molecular Weight | 712.64 |